Studies suggest that other factors also contribute to handedness. The prenatal environment and cultural influences may play a role. Like many complex traits, handedness does not have a simple pattern of inheritance.
Children of left-handed parents are more likely to be left-handed than are children of right-handed parents. However, because the overall chance of being left-handed is relatively low, most children of left-handed parents are right-handed.
Identical twins are more likely than non-identical twins or other siblings to be either right-handed or left-handed, but many twins have opposite hand preferences. Genome-wide association study of handedness excludes simple genetic models. Heredity Edinb. Epub Sep PubMed: PLoS Genet. Brandler WM, Paracchini S. The genetic relationship between handedness and neurodevelopmental disorders. Trends Mol Med.
Scientists confirm genetics of schizophrenia. The study also indicated an association between the aspects of brain development linked to handedness and the likelihood of developing schizophrenia or Parkinson's disease. Dominic Furniss, joint senior author alongside Douaud and a fellow at Oxford's Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Science told CNN, "It has long been known that there are slightly more left-handers amongst patients with schizophrenia than the general population.
By contrast, there are slightly less left-handers with Parkinson's disease than the general population. The new research, Furniss said, "suggests that these diseases, along with handedness, are the product of fundamental differences in brain development, some of which is driven by genes. Since 90 per cent of the population is right-handed, left-handed people do experience some practical problems, including:.
This page has been produced in consultation with and approved by:. The abdominal muscles support the trunk, allow movement and hold organs in place by regulating internal abdominal pressure.
People who run regularly seem to be susceptible to Achilles tendonitis. Acromegaly is caused by an excess of growth hormone in adults, which causes the overgrowth of bones in the face, hands, feet and internal organs. Exercise can prevent age-related changes to muscles, bones and joints and can reverse these changes too.
A person with amyloidosis produces aggregates of insoluble protein that cannot be eliminated from the body. Content on this website is provided for information purposes only. Information about a therapy, service, product or treatment does not in any way endorse or support such therapy, service, product or treatment and is not intended to replace advice from your doctor or other registered health professional.
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The State of Victoria and the Department of Health shall not bear any liability for reliance by any user on the materials contained on this website. Skip to main content. Babies and toddlers Home Babies and toddlers Actions for this page Listen Print. Summary Read the full fact sheet. The relatively modest effect sizes of the associated variants, and the heritability estimate of handedness explained by all SNPs in the left- versus right-handers GWAS 0.
Similarly, the strongest effect of handedness in the brain explained about 1. This is the first study to identify in the general population genome-wide significant loci for human handedness in, and eQTL of, genes associated with brain development, microtubules and patterning.
Thus, this locus has biological plausibility in contributing to differences in neurodevelopmental connectivity of language areas. The lateralization of brain language function was strongly related to handedness; whether increased bilateral language function gives left-handers a cognitive advantage at verbal tasks remains to be investigated separately in a large dataset offering both well-characterized verbal cognition testing not available in UK Biobank as well as FSLnets-like functional connectivity measures, such as the Human Connectome Project Anticevic et al.
This study thus represents an important advance in our understanding of human handedness and offers mechanistic insights into the observed correlations between chirality and microtubules in the brain, and suggests an overlap of genetic architecture between handedness and certain neurodegenerative and psychiatric phenotypes.
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